Indications:

The joint 2014 American College of Cardiology (ACC) and American Heart Association (AHA) guidelines for the indication of PTMC in MS are as follows:

Symptomatic patients

  • Class I (LOE A) – Severe MS (mitral valve area ≤1.5 cm2) with favourable valve morphology and without left atrial thrombus or moderate to severe mitral regurgitation (MR).

  • Class IIb (LOE C) – MS with MV area >1.5 cm2 with significant hemodynamic changes on exercise consisting of a pulmonary artery wedge pressure ≥25 mm Hg or mean MV gradient >15 mm Hg.

  • Class IIb (C) – High surgical risk patients with severe MS (mitral valve area ≤1.5 cm2) and suboptimal valve anatomy.

Asymptomatic patients

  • Class IIa (LOE C) – Very severe MS (mitral valve area ≤1.0 cm2), favourable valve morphology, and without left atrial thrombus or moderate to severe mitral regurgitation (MR).

  • Class IIb (LOE C) – Severe MS (mitral valve area ≤1.5 cm2) with favourable valve morphology and without left atrial thrombus or moderate to severe mitral regurgitation (MR).